Irritable Bowel Syndrome (IBS)IBS has numerous contributing factors, affecting approximately 10–20% of individuals in developed countries. It presents as functional gastrointestinal disturbances without identifiable organic causes.
The enhancement of the antinociceptive properties of cannabinoids in the presence of inflammation highlights the significance of the ECS in the expression of visceral hypersensitivity. This finding not only elucidates the mechanisms underlying conditions like IBS and other gastrointestinal disorders but also suggests promising therapeutic paths for relieving abdominal and visceral pain.
Cannabinoids alone may not provide substantial relief in reducing visceral hypersensitivity among IBS patients. Investigating combinations with other pain-modulating agents, such as opioids, offers an intriguing alternative avenue worth exploring.
Inflammatory Bowel Disease (IBD)
IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex condition affecting the GI tract. These diseases arise from environmental, genetic, and epigenetic factors.
Cannabidiol exhibits strong anti-inflammatory properties across various models of intestinal inflammation in mice and rats, as noted in a study published in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD demonstrated a dose-dependent improvement in disease markers:
- The reduction of structural damage
- The mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.
A study from the Inflammatory Diseases Journal indicated that the primary finding of their research was the challenging tolerability of the botanical extract, with 90% of participants reporting treatment-related adverse effects compared to 48% receiving the placebo.
A trend emerged towards improved quality of life scores and a positive shift in patients’ overall impression of change, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract might offer therapeutic advantages to those patients who can tolerate its effects.
Gastrointestinal Cancer
GI cancers, including colorectal cancer (CRC), are among the most frequently diagnosed conditions in the general population.
Numerous studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, boost endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.
Confirmation of CBD’s chemopreventive properties was obtained through the examination of in vivo models focusing on AOM-induced colon cancer. CBD at a dosage of 1 mg/kg resulted in a significant reduction: ACF decreased by 67%, while the count of tumors and polyps dropped by 66% and 57%, respectively. An increase in concentration to 5 mg/kg showed efficacy mainly in preventing polyp formation.
THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.
Nausea and Vomiting
Positive effects of CBD occur when combined with THC, as indicated in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic properties may be due to the indirect stimulation of somatodendritic 5-HT1A receptors located in the dorsal raphe nucleus. This activation of autoreceptors potentially leads to a reduction in the release of 5-HT in specific forebrain regions.
Gastroesophageal Reflux Disease (GERD)
Cannabinoids inhibit transient LES relaxations via a CB1-dependent mechanism in both dogs and ferrets, as reported in a study from the Journal of cannabis and Cannabinoid Research. These findings are significant as transient LES relaxations are the primary mechanism underlying gastroesophageal reflux disease.
Cannabis Sativa for GI Issues
Conclusion
Numerous studies indicate that the advantages of cannabinoids apply not only to the well-known psychoactive compound THC but also to non-psychoactive compounds like CBD and others, which have received comparatively less examination. The cannabis plant affects the GI system by engaging with the ECS to activate various functions that can help manage symptoms of specific GI conditions.
Frequently Asked Questions
What can you expect when buying from online cannabis stores?
- Accessing your cannabis products in Canada from an online store provides many options featuring both classic favorites and new offerings.
- You can expect additional perks such as exclusive deals, secure payment methods, and shipping options covering most provinces.
- Essential resources, such as a blog section or contact page, are available to offer customers insights or support during their shopping experience.
- As part of the purchasing process, you’ll need to verify or confirm your age by presenting identification.
- Some stores include taxes in their product prices, while others calculate it at checkout.
- Some dispensaries accept online payments like Interac E-Transfer, while others allow cash on delivery.
What is the measurement unit when buying from a cannabis website?
There are two main types of measurement: metric and imperial units. On a cannabis site, you will find measurements in grams or ounces, allowing you to locate products like 3.5 grams or 1/8 ounces.
What distinguishes cannabis for medical use from that used recreationally?
Medical cannabis and recreational cannabis come from the same plant species, yet their differing effects and intended uses set them apart. Medical cannabis acts as a therapeutic aid for specific health conditions, with a higher CBD content compared to its recreational counterpart.
Are there ready-made joints available in a cannabis store?
Yes. These are available as pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, are convenient options for those who prefer their cannabis ready to use. There is a growing trend in the popularity of pre-rolled joints infused with cannabis concentrates.
Do cannabis online stores have a physical shop?
Not all online stores have physical locations, meaning you can have your purchases delivered directly to your home instead of needing to pick them up from a physical outlet after placing an online order.
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